Highlights•Advances in ALR mediated inflammasome activation in response to viral
DNA.•Viral virulence factors that impair inflammasome activation.•Host regulation of …

The innate immune system is composed of a wide repertoire of conserved pattern
recognition receptors (PRRs) able to trigger inflammation and host defense mechanisms in …

Uncontrolled inflammatory response arising from the tumor microenvironment (TME)
significantly contributes to cancer progression, prompting an investigation and careful …

In addition to its roles in controlling infection and tissue repair, inflammation plays a critical
role in diverse and distinct chronic diseases, such as cancer, metabolic syndrome, and …

Based on a recent report concerning endogenous agents (ie, pyridoxal phosphate,
adenosine triphosphate, adenosine monophosphate, folinic acid) that modulate the …

Inflammasomes are protein complexes that promote the maturation and release of pro‐
inflammatory cytokines and danger signals as well as pyroptosis in response to infections …

Oxidative stress and inflammation play a role in the physiopathology of insulin resistance,
diabetes and cardiovascular disease. A single high-fat, high-carbohydrate (HFHC) meal …

The promyelocytic leukemia (PML) protein is a tumor suppressor acting as the organizer of
nuclear matrix-associated structures named nuclear bodies (NBs). The involvement of PML …

Inflammasome activity is important for the immune response and is instrumental in
numerous clinical conditions. Here we identify a mechanism that modulates the central …

NOD1 is a member of nucleotide-binding oligomerization domain-like receptors family that
participates in many inflammatory processes. Previous studies demonstrated that NOD1 …