In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) treatment induces
granulocytic maturation and complete remission of leukemia. microRNAs are known to be …

STMN1 belongs to the stathmin gene family, it encodes a cytoplasmic phosphorylated
protein, stathmin1, which is commonly observed in vertebrate cells. STMN1 is a structural …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a
progressive upper and lower motor neuron degeneration. One of the peculiar clinical …

Summary Stathmin 1 (STMN1) is a microtubule-destabilizing protein highly expressed in
hematological malignancies and involved in proliferation and differentiation. Although a …

Proteomics technologies are emerging as a useful tool in the identification of disease
biomarkers, and in defining and characterising both normal physiological and disease …

Background The proteasome inhibitor bortezomib represents an important advance in the
treatment of multiple myeloma (MM). Bortezomib inhibits the activity of the 26S proteasome …

The JAK/STAT pathway is constitutively activated in myeloproliferative neoplasms and can
be inhibited by ruxolitinib, a selective JAK1/2 inhibitor. The JAK2 V617F mutation leads to …

Despite the great advances in the understanding of the molecular basis of acute leukemia,
very little of this knowledge has been translated into new therapies. Stathmin 1 (STMN1), a …

Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by
abnormal proliferation and accumulation of lymphoblasts in the hematopoietic system …

急性髓系白血病作为一种复发率高的造血系统恶性肿瘤, 其分子机制, 预后预测以及药物反应
一直是这个疾病诊疗的关键, 而近年来飞速发展的蛋白质组学技术也逐渐进入了急性髓系白血病 …