Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

It is estimated that more than 339 million people worldwide suffer from asthma. The leading
cause of asthma development is the breakdown of immune tolerance to inhaled allergens …

Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …

Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

The GRADE (Grades of Recommendation, Assessment, Development, and Evaluation)
approach provides guidance to grading the quality of underlying evidence and the strength …

Background Allergen specific immunotherapy has long been a controversial treatment for
asthma. Although beneficial effects upon clinically relevant outcomes have been …

Asthma is the leading chronic disease among children in most industrialized countries.
However, the evidence base on specific aspects of pediatric asthma, including therapeutic …

Allergen immunotherapy is effective in patients with allergic rhinitis (AR) and, unlike
antiallergic drugs, has been shown to modify the underlying cause of the disease, with …

Sublingual immunotherapy (SLIT) has gained wide accep-tance in many European
countries and has raised the level of interest in immunotherapy among practicing allergists …

This paper was produced to establish a common European Standard for Practical Allergen-
Specific Immunotherapy that could serve as an overall Ôgold standardÕ to ensure optimum …