Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation
that plays a major role in immunosenescence and in development and progression of many …

Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …

NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of
diseases. Identification of endogenous inflammasome activators is essential for the …

Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its
pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the …

Background Acute kidney injury is common, with a major effect on morbidity and health care
utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling …

People with kidney disease are disproportionately affected by atherosclerosis for unclear
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic
kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants …

Although glucocorticoids are the mainstays in the treatment of renal diseases for decades,
the dose dependent side effects have largely restricted their clinical use. Microvesicles …