Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
Soluble urokinase plasminogen activator receptor (suPAR) as a biomarker of systemic chronic inflammation
LJH Rasmussen, JEV Petersen… - Frontiers in …, 2021 - frontiersin.org
Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation
that plays a major role in immunosenescence and in development and progression of many …
that plays a major role in immunosenescence and in development and progression of many …
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation
S Zewinger, J Reiser, V Jankowski, D Alansary… - Nature …, 2020 - nature.com
NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of
diseases. Identification of endogenous inflammasome activators is essential for the …
diseases. Identification of endogenous inflammasome activators is essential for the …
Soluble urokinase receptor (SuPAR) in COVID-19–related AKI
Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its
pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the …
pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the …
Soluble urokinase receptor and acute kidney injury
Background Acute kidney injury is common, with a major effect on morbidity and health care
utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling …
utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling …
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
People with kidney disease are disproportionately affected by atherosclerosis for unclear
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …
Ion channels and channelopathies in glomeruli
A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease
Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic
kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants …
kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants …
[HTML][HTML] Employing macrophage-derived microvesicle for kidney-targeted delivery of dexamethasone: an efficient therapeutic strategy against renal inflammation and …
Although glucocorticoids are the mainstays in the treatment of renal diseases for decades,
the dose dependent side effects have largely restricted their clinical use. Microvesicles …
the dose dependent side effects have largely restricted their clinical use. Microvesicles …