Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

The developing human fetus generates both tolerogenic and protective immune responses
in response to the unique requirements of gestation. Thus, a successful human pregnancy …

Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function
variants in IKZF1 cause primary immunodeficiency, but Ikaros family members IKZF2 and …

Accumulation of immune cells and activation of the pro-inflammatory transcription factor NF-
κB in feto-maternal uterine tissues is a key feature of preterm birth (PTB) pathophysiology …

Treg therapy holds promise as a potentially curative approach to establish immune
tolerance in transplantation and autoimmune disease. An outstanding question is whether …

Pregnancy is a state of immunological balance during which the mother and the developing
fetus must tolerate each other while maintaining sufficient immunocompetence to ward off …

We are just beginning to understand the diversity of the peripheral T cell compartment,
which arises from the specialization of different T cell subsets and the plasticity of individual …

Regulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of
immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex …