2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk The Task Force for the management of …

F Mach, C Baigent, AL Catapano… - European heart …, 2020 - academic.oup.com
version of the Guidelines, which is freely available via the ESC and EAS websites and
hosted on their journals' websites (EHJ and Atherosclerosis Journal). The National Cardiac …

Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy

S Kraler, MC Blaser, E Aikawa, GG Camici… - European heart …, 2022 - academic.oup.com
Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Lipoprotein (a), PCSK9 inhibition, and cardiovascular risk: insights from the FOURIER trial

ML O'Donoghue, S Fazio, RP Giugliano, ESG Stroes… - Circulation, 2019 - Am Heart Assoc
Background: Lipoprotein (a)[Lp (a)] may play a causal role in atherosclerosis. PCSK9
(proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce …

Use of Lipoprotein (a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association

DP Wilson, TA Jacobson, PH Jones… - Journal of clinical …, 2019 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a well-recognized, independent risk factor for
atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in …

A test in context: lipoprotein (a) diagnosis, prognosis, controversies, and emerging therapies

S Tsimikas - Journal of the American College of Cardiology, 2017 - jacc.org
Evidence that elevated lipoprotein (a)(Lp [a]) levels contribute to cardiovascular disease
(CVD) and calcific aortic valve stenosis (CAVS) is substantial. Development of isoform …

Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the writing committee of the American society for apheresis: the …

J Schwartz, A Padmanabhan, N Aqui… - Journal of clinical …, 2016 - Wiley Online Library
The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA) Special
Issue Writing Committee is charged with reviewing, updating, and categorizing indications …

Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial

FJ Raal, N Honarpour, DJ Blom, GK Hovingh, F Xu… - The Lancet, 2015 - thelancet.com
Background Homozygous familial hypercholesterolaemia is a rare, serious disorder caused
by very low or absent plasma clearance of LDL, substantially raised LDL cholesterol, and …

[HTML][HTML] Lipid metabolism, disorders and therapeutic drugs–review

V Natesan, SJ Kim - Biomolecules & therapeutics, 2021 - ncbi.nlm.nih.gov
Different lifestyles have an impact on useful metabolic functions, causing disorders. Different
lipids are involved in the metabolic functions that play various vital roles in the body, such as …

Novel and future lipid-modulating therapies for the prevention of cardiovascular disease

J Brandts, KK Ray - Nature Reviews Cardiology, 2023 - nature.com
Lowering the levels of LDL cholesterol in the plasma has been shown to reduce the risk of
atherosclerotic cardiovascular disease (ASCVD). Several other lipoproteins, such as …