Parkinson's disease (PD) is one of the most common degenerative brain disorders caused
by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and …

Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the
diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is …

Maternal hyperhomocysteinemia is one of the common complications of pregnancy that
causes offspring cognitive deficits during postnatal development. In this study, we …

Maternal hyperhomocysteinemia causes the disruption of placental blood flow and can lead
to serious disturbances in the formation of the offspring's brain. In the present study, the …

Early markers are needed for more effective prevention of Alzheimer's disease. We
previously showed that individuals with Alzheimer's disease have decreased plasma …

Homocysteine (Hcy) is produced through methionine transmethylation. Elevated Hcy levels
are termed Hyperhomocysteinemia (HHcy) and represent a risk factor for neurodegenerative …

Aromatic l-amino acid decarboxylase deficiency (AADC-DY) is caused by one or more
mutations in the DDC gene, resulting in the deficit in catecholamines and serotonin …

Aims Throughout gestation, proteins in the diet are a source of essential amino acids that
are crucial for proper healthy fetal growth and development. The present study was …

Tetrahydrobiopterin (BH4) is a vital coenzyme for several enzymes involved in diverse
enzymatic reactions in animals, and BH4 deficiency can lead to metabolic and neurological …

Alzheimer's disease is a neurodegenerative disorder with polygenic etiology. Genetic risk
variants for Alzheimer's disease differ among populations. Thus, discovering them in each …