Tailor‐Made Auxiliaries for Polar Growth from Melts

B Kahr, AG Shtukenberg, J Yang… - Israel Journal of …, 2021 - Wiley Online Library
Tailor‐made auxiliaries are generally less stereochemically discriminating of crystals grown
from the melt than crystals grown from solution. However, it is possible to make …

Investigation of the Binary System of Proxyphylline Enantiomers: Structural Resolution and Phase Diagram Determination

C Pinetre, L Harfouche, C Brandel… - Molecular …, 2023 - ACS Publications
The solid-state landscape of proxyphylline (PXL), a chiral derivative of theophylline
crystallizing as a racemic compound, was extensively investigated by means of thermal …

Investigation of drug–excipient interactions in biclotymol amorphous solid dispersions

B Schammé, N Couvrat, V Tognetti… - Molecular …, 2018 - ACS Publications
The effect of low molecular weight excipients on drug–excipient interactions, molecular
mobility, and propensity to recrystallization of an amorphous active pharmaceutical …

Vitrification of two active pharmaceutical ingredients by fast scanning calorimetry: from structural relaxation to nucleation phenomena

X Monnier, Q Viel, B Schammé, S Petit… - International Journal of …, 2018 - Elsevier
Cinchonidine and Theophylline vitrification abilities have been investigated by differential
and fast scanning calorimetry. These active pharmaceutical compounds are known in the …

Molecular mobility of an amorphous chiral pharmaceutical compound: impact of chirality and chemical purity

Q Viel, L Delbreilh, G Coquerel, S Petit… - The Journal of …, 2017 - ACS Publications
A dielectric relaxation spectroscopy (DRS) study was performed to investigate the molecular
mobility of amorphous chiral diprophylline (DPL). For this purpose, both racemic DPL and a …