Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Review of distribution, extraction methods, and health benefits of bound phenolics in food plants
Phenolic compounds are important functional bioactive substances distributed in various
food plants. They have gained wide interest from researchers due to their multiple health …
food plants. They have gained wide interest from researchers due to their multiple health …
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial neurological disorder among elderly people and
combinatorial factors such as genetic, lifestyle, and environmental are involved in onset and …
combinatorial factors such as genetic, lifestyle, and environmental are involved in onset and …
Multifunctional compounds: Smart molecules for multifactorial diseases
Y Bansal, O Silakari - European Journal of Medicinal Chemistry, 2014 - Elsevier
Multifunctional compounds (MFCs) are designed broadly as hybrid or conjugated drugs or
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …
neurodegenerative disorder of the brain which involves multiple associated etiological …
Multitarget compounds bearing tacrine-and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
L Ismaili, B Refouvelet, M Benchekroun, S Brogi… - Progress in …, 2017 - Elsevier
Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
Hybrid molecules based on caffeic acid as potential therapeutics: A focused review
X Zhao, Z Liu, H Liu, J Guo, S Long - European Journal of Medicinal …, 2022 - Elsevier
Caffeic acid-based compounds possess a high degree of structural diversity and show a
variety of pharmacological properties, providing a useful framework for the discovery of new …
variety of pharmacological properties, providing a useful framework for the discovery of new …
Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015)
SF McHardy, HYL Wang, SV McCowen… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes
acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline …
acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline …