Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Plasma membrane phospholipid signature recruits the plant exocyst complex via the EXO70A1 subunit

L Synek, R Pleskot, J Sekereš… - Proceedings of the …, 2021 - National Acad Sciences
Polarized exocytosis is essential for many vital processes in eukaryotic cells, where
secretory vesicles are targeted to distinct plasma membrane domains characterized by their …

The Regulation of Exosome Generation and Function in Physiological and Pathological Processes

Y Wang, T Xiao, C Zhao, G Li - International Journal of Molecular …, 2023 - mdpi.com
Exosomes, a type of extracellular vesicle with a diameter of approximately 100 nm that is
secreted by all cells, regulate the phenotype and function of recipient cells by carrying …

The exocyst complex in health and disease

M Martin-Urdiroz, MJ Deeks, CG Horton… - Frontiers in Cell and …, 2016 - frontiersin.org
Exocytosis involves the fusion of intracellular secretory vesicles with the plasma membrane,
thereby delivering integral membrane proteins to the cell surface and releasing material into …

Exocyst SEC3 and phosphoinositides define sites of exocytosis in pollen tube initiation and growth

D Bloch, R Pleskot, P Pejchar, M Potocký… - Plant …, 2016 - academic.oup.com
Polarized exocytosis is critical for pollen tube growth, but its localization and function are still
under debate. The exocyst vesicle-tethering complex functions in polarized exocytosis …

Tethering complexes in the Arabidopsis endomembrane system

N Vukašinović, V Žárský - Frontiers in cell and developmental biology, 2016 - frontiersin.org
Targeting of endomembrane transport containers is of the utmost importance for proper land
plant growth and development. Given the immobility of plant cells, localized membrane …

Exocyst functions in plants: secretion and autophagy

V Žárský - FEBS letters, 2022 - Wiley Online Library
Tethering complexes mediate vesicle–target compartment contact. Octameric complex
exocyst initiate vesicle exocytosis at specific cytoplasmic membrane domains. Plant exocyst …

Exocyst subunit Exo70B2 is linked to immune signaling and autophagy

C Brillada, OK Teh, FA Ditengou, CW Lee… - The Plant …, 2021 - academic.oup.com
During the immune response, activation of the secretory pathway is key to mounting an
effective response, while gauging its output is important to maintain cellular homeostasis …

[HTML][HTML] Role of charged lipids in membrane structures—Insight given by simulations

S Pöyry, I Vattulainen - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
Lipids and proteins are the main components of cell membranes. It is becoming increasingly
clear that lipids, in addition to providing an environment for proteins to work in, are in many …