Post-translational regulation of Runx2 in bone and cartilage
JH Jonason, G Xiao, M Zhang… - Journal of dental …, 2009 - journals.sagepub.com
The Runx2 gene product is essential for mammalian bone development. In humans, Runx2
haploinsufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by …
haploinsufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by …
Runx2 and dental development
S Camilleri, F McDonald - European journal of oral sciences, 2006 - Wiley Online Library
The Runx2 gene is a master transcription factor of bone and plays a role in all stages of
bone formation. It is essential for the initial commitment of mesenchymal cells to the …
bone formation. It is essential for the initial commitment of mesenchymal cells to the …
[HTML][HTML] A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
K Adhikari, M Fuentes-Guajardo… - Nature …, 2016 - nature.com
We report a genome-wide association scan for facial features in∼ 6,000 Latin Americans.
We evaluated 14 traits on an ordinal scale and found significant association (P values< 5× …
We evaluated 14 traits on an ordinal scale and found significant association (P values< 5× …
RUNX2 regulates osteoblast differentiation via the BMP4 signaling pathway
DD Liu, CY Zhang, Y Liu, J Li… - Journal of dental …, 2022 - journals.sagepub.com
RUNX2 is a master osteogenic transcription factor, and mutations in RUNX2 cause the
inherited skeletal disorder cleidocranial dysplasia (CCD). Studies have revealed that …
inherited skeletal disorder cleidocranial dysplasia (CCD). Studies have revealed that …
[HTML][HTML] Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2
Y Zhang, R Xie, J Gordon, K LeBlanc, JL Stein… - Journal of Biological …, 2012 - ASBMB
Multiple microRNAs (miRNAs) that target the osteogenic Runt-related transcription factor 2
(RUNX2) define an interrelated network of miRNAs that control osteoblastogenesis. We …
(RUNX2) define an interrelated network of miRNAs that control osteoblastogenesis. We …
[HTML][HTML] Functional consequences of C-terminal mutations in RUNX2
S Thaweesapphithak, T Theerapanon… - Scientific Reports, 2023 - nature.com
Cleidocranial dysplasia (CCD) is a genetic disorder caused by mutations in the RUNX2
gene, affecting bone and teeth development. Previous studies focused on mutations in the …
gene, affecting bone and teeth development. Previous studies focused on mutations in the …
Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome
D Napierala, K Sam, R Morello, Q Zheng… - Human molecular …, 2008 - academic.oup.com
Tricho-rhino-phalangeal syndrome (TRPS) is an autosomal dominant craniofacial and
skeletal dysplasia that is caused by mutations involving the TRPS1 gene. Patients with …
skeletal dysplasia that is caused by mutations involving the TRPS1 gene. Patients with …
Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression
R Rangel, SC Lee, K Hon-Kim Ban… - Proceedings of the …, 2016 - National Acad Sciences
Triple-negative breast cancer (TNBC) has the worst prognosis of any breast cancer subtype.
To better understand the genetic forces driving TNBC, we performed a transposon …
To better understand the genetic forces driving TNBC, we performed a transposon …
[HTML][HTML] Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3
M Wuelling, FJ Kaiser, LA Buelens, D Braunholz… - Developmental …, 2009 - Elsevier
Trps1, the gene mutated in human Tricho-Rhino-Phalangeal syndrome, represents an
atypical member of the GATA-family of transcription factors. Here we show that Trps1 …
atypical member of the GATA-family of transcription factors. Here we show that Trps1 …
Deletions of the RUNX2 gene are present in about 10% of individuals with cleidocranial dysplasia
CE Ott, G Leschik, F Trotier, L Brueton… - Human …, 2010 - Wiley Online Library
Cleidocranial Dysplasia (CCD) is an autosomal dominant skeletal disorder characterized by
hypoplastic or absent clavicles, increased head circumference, large fontanels, dental …
hypoplastic or absent clavicles, increased head circumference, large fontanels, dental …