The Runx2 gene product is essential for mammalian bone development. In humans, Runx2
haploinsufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by …

The Runx2 gene is a master transcription factor of bone and plays a role in all stages of
bone formation. It is essential for the initial commitment of mesenchymal cells to the …

We report a genome-wide association scan for facial features in∼ 6,000 Latin Americans.
We evaluated 14 traits on an ordinal scale and found significant association (P values< 5× …

RUNX2 is a master osteogenic transcription factor, and mutations in RUNX2 cause the
inherited skeletal disorder cleidocranial dysplasia (CCD). Studies have revealed that …

Multiple microRNAs (miRNAs) that target the osteogenic Runt-related transcription factor 2
(RUNX2) define an interrelated network of miRNAs that control osteoblastogenesis. We …

Cleidocranial dysplasia (CCD) is a genetic disorder caused by mutations in the RUNX2
gene, affecting bone and teeth development. Previous studies focused on mutations in the …

Tricho-rhino-phalangeal syndrome (TRPS) is an autosomal dominant craniofacial and
skeletal dysplasia that is caused by mutations involving the TRPS1 gene. Patients with …

Triple-negative breast cancer (TNBC) has the worst prognosis of any breast cancer subtype.
To better understand the genetic forces driving TNBC, we performed a transposon …

Trps1, the gene mutated in human Tricho-Rhino-Phalangeal syndrome, represents an
atypical member of the GATA-family of transcription factors. Here we show that Trps1 …

Cleidocranial Dysplasia (CCD) is an autosomal dominant skeletal disorder characterized by
hypoplastic or absent clavicles, increased head circumference, large fontanels, dental …