Allergic inflammation is due to a complex interplay between several inflammatory cells,
including mast cells, basophils, lymphocytes, dendritic cells, eosinophils, and sometimes …

abstract Leukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and
LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are …

Nuclear factor kappa B (NFκB) is a transcription factor belonging to 'Rel'family that
represents a crucial intracellular signal transduction system involved in several inflammatory …

Effective treatment of severe asthma is a major unmet need because patients' symptoms are
not controlled on maximum treatment with inhaled therapy. Asthma symptoms can be poorly …

Leukotrienes are clearly involved in airway inflammation and certain clinical features of
asthma. Evolving evidence indicates that leukotriene B 4 has an important role in the …

Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes,
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …

The leukotrienes are important lipid mediators with immune modulatory and proinflammatory
properties. Classical bioactions of leukotrienes include chemotaxis, endothelial adherence …

Summary Leukotrienes (LTs), including cysteinyl LTs (CysLTs) and LTB4, are potent lipid
mediators that have a role in the pathophysiology of asthma. At least two receptor subtypes …

Leukotriene B4 (LTB4) receptor type 2 (BLT2) is a G protein–coupled receptor (GPCR) for
12 (S)-hydroxyheptadeca-5 Z, 8 E, 10 E-trienoic acid (12-HHT) and LTB4. Despite the well …

For several decades, the leukotriene pathways have been implicated as playing a central
role in the pathophysiology of asthma. The presence and elevation of numerous metabolites …