Time-correlated single photon counting (TCSPC) is a widely used, robust and mature
technique to measure the photon arrival time in applications such as fluorescence …

Non-invasive measurement of drug-target engagement can provide critical insights in the
molecular pharmacology of small molecule drugs. Fluorescence polarization/fluorescence …

In the present study, a novel in situ forming thermosensitive hydrogel system was
investigated as a versatile drug delivery system for ocular therapy. For this purpose, two …

Focused ultrasound combined with microbubble-mediated intranasal delivery (FUSIN) is a
new brain drug delivery technique. FUSIN utilizes the nasal route for direct nose-to-brain …

Patients with wet age-related macular degeneration (AMD) require intravitreal injections of
bevacizumab (Bev) or other drugs, often on a monthly basis, which is a burden on the …

Personalized Computational Hemodynamics: Models, Methods, and Applications for
Vascular Surgery and Antitumor Therapy offers practices and advances surrounding the …

Förster resonance energy transfer (FRET) is a powerful tool to investigate the interaction
between proteins in living cells. Fluorescence proteins, such as the green fluorescent …

Therapeutic antibodies administered intravitreally are the current standard of care to treat
retinal diseases. The ocular half-life (t 1/2) is a key determinant of the duration of target …

With a view to improve the current monoclonal antibody-based therapies dominating the
pharmaceutical market, low molecular weight (MW) protein-based macromolecules, such as …

BACKGROUND: Retinal degenerative disease (RDD), one of the most common causes of
blindness, is predominantly caused by the gradual death of retinal pigment epithelial cells …