Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …

The intent of this review is to describe what is known and unknown about telomerase in
somatic cells of the human organism. First, we consider the telomerase enzyme. Human …

Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …

Telomerase is a eukaryotic ribonucleoprotein (RNP) whose specialized reverse
transcriptase action performs de novo synthesis of one strand of telomeric DNA. The …

The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …