Regulation of human telomerase in homeostasis and disease
CM Roake, SE Artandi - Nature reviews Molecular cell biology, 2020 - nature.com
Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …
Human telomerase and its regulation
YS Cong, WE Wright, JW Shay - Microbiology and molecular …, 2002 - Am Soc Microbiol
The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
Cryo-EM structure of substrate-bound human telomerase holoenzyme
THD Nguyen, J Tam, RA Wu, BJ Greber, D Toso… - Nature, 2018 - nature.com
The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …
telomeres during genome replication. Telomerase regulation has been implicated in cancer …
Finding the end: recruitment of telomerase to telomeres
J Nandakumar, TR Cech - Nature reviews Molecular cell biology, 2013 - nature.com
Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
Telomerase mechanism of telomere synthesis
RA Wu, HE Upton, JM Vogan… - Annual review of …, 2017 - annualreviews.org
Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …
Telomerase in the human organism
K Collins, JR Mitchell - Oncogene, 2002 - nature.com
The intent of this review is to describe what is known and unknown about telomerase in
somatic cells of the human organism. First, we consider the telomerase enzyme. Human …
somatic cells of the human organism. First, we consider the telomerase enzyme. Human …
Molecular mechanisms of telomere biology disorders
S Grill, J Nandakumar - Journal of Biological Chemistry, 2021 - ASBMB
Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …
Telomerase: an RNP enzyme synthesizes DNA
EH Blackburn, K Collins - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Telomerase is a eukaryotic ribonucleoprotein (RNP) whose specialized reverse
transcriptase action performs de novo synthesis of one strand of telomeric DNA. The …
transcriptase action performs de novo synthesis of one strand of telomeric DNA. The …
The structure and function of telomerase reverse transcriptase
C Autexier, NF Lue - Annu. Rev. Biochem., 2006 - annualreviews.org
The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …
Telomerase: structure, functions, and activity regulation
MI Zvereva, DM Shcherbakova, OA Dontsova - Biochemistry (Moscow), 2010 - Springer
Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …