The role of miRNAs in liver diseases: Potential therapeutic and clinical applications
AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
MicroRNAs (miRNAs) are a class of short, non-coding RNAs that function post-
transcriptionally to regulate gene expression by binding to particular mRNA targets and …
transcriptionally to regulate gene expression by binding to particular mRNA targets and …
Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease
C Yan, W Hu, J Tu, J Li, Q Liang, S Han - Journal of Translational …, 2023 - Springer
Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …
[HTML][HTML] The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation
AL Wozniak, A Adams, KE King, W Dunn… - Journal of Cell …, 2020 - rupress.org
Cells respond to inflammatory disease states by releasing exosomes containing highly
specific protein and RNA cargos, but how inflammation alters cargo specificity and secretion …
specific protein and RNA cargos, but how inflammation alters cargo specificity and secretion …
MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47phox–oxidative stress pathway in neutrophils
Objectives Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver
injury in mice. This study investigates how recent excessive drinking affects peripheral …
injury in mice. This study investigates how recent excessive drinking affects peripheral …
Disturbances in cholesterol homeostasis and non-alcoholic fatty liver diseases
P Malhotra, RK Gill, S Saksena, WA Alrefai - Frontiers in Medicine, 2020 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a major health problem associated with obesity
and other features of the metabolic syndrome including insulin resistance and dyslipidemia …
and other features of the metabolic syndrome including insulin resistance and dyslipidemia …
Mechanism of cargo sorting into small extracellular vesicles
Y Chen, Y Zhao, Y Yin, X Jia, L Mao - Bioengineered, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are special membranous structures released by almost every
cell type that carry and protect some biomolecules from being degraded. They transport …
cell type that carry and protect some biomolecules from being degraded. They transport …
Molecular and cellular mediators of the gut-liver axis in the progression of liver diseases
A Bruneau, J Hundertmark, A Guillot, F Tacke - Frontiers in Medicine, 2021 - frontiersin.org
The gut-liver axis covers the bidirectional communication between the gut and the liver, and
thus includes signals from liver-to-gut (eg, bile acids, immunoglobulins) and from gut-to-liver …
thus includes signals from liver-to-gut (eg, bile acids, immunoglobulins) and from gut-to-liver …
Aging exaggerates acute‐on‐chronic alcohol‐induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1‐C/EBPα‐miRNA‐223 axis
Abstract Background and Aims Aging exacerbates liver neutrophil infiltration and alcohol‐
associated liver disease (ALD) in mice and humans, but the underlying mechanisms remain …
associated liver disease (ALD) in mice and humans, but the underlying mechanisms remain …
A pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease
Y Tan, G Ge, T Pan, D Wen, J Gan - PloS one, 2014 - journals.plos.org
Background The invasive nature of liver biopsy makes the histopathological diagnosis of
non-alcoholic fatty liver disease (NAFLD) difficult and its diagnostic performance …
non-alcoholic fatty liver disease (NAFLD) difficult and its diagnostic performance …
Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers, and therapeutic prospective
Alcohol-associated liver disease (ALD) comprises a spectrum of liver diseases that include:
steatosis to alcohol-associated hepatitis, cirrhosis, and ultimately hepatocellular carcinoma …
steatosis to alcohol-associated hepatitis, cirrhosis, and ultimately hepatocellular carcinoma …