The genome is a sequence that encodes the DNA, RNA, and proteins that orchestrate an
organism's function. We present Evo, a long-context genomic foundation model with a …

Directed protein evolution is central to biomedical applications but faces challenges like
experimental complexity, inefficient multi-property optimization, and local maxima traps …

Determining the specificity of adaptive immune receptors—B cell receptors (BCRs), their
secreted form antibodies, and T cell receptors (TCRs)—is critical for understanding immune …

The adaptive immune system holds invaluable information on past and present immune
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …

Increasing the binding affinity of an antibody to its target antigen is a crucial task in antibody
therapeutics development. This paper presents a pretrainable geometric graph neural …

The work by Hassabis and Jumper on protein structure prediction together with Baker's
supremacy in de novo protein design set the stage for a future where AI not only deciphers …

Directed evolution of proteins is critical for applications in basic biological research,
therapeutics, diagnostics, and sustainability. However, directed evolution methods are labor …

Tailor-made enzymes empower a wide range of versatile applications, although searching
for the desirable enzymes often requires high throughput screening and thus poses …

Study of mechanisms by which antibodies recognize different viral strains is necessary for
the development of new drugs and vaccines to treat COVID-19 and other infections. Here …

Allostery represents a fundamental mechanism in protein regulation, enabling modulation of
protein function from sites distal to the active site. While traditionally explored in the context …