Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

The ipd-imgt/hla database

DJ Barker, G Maccari, X Georgiou… - Nucleic acids …, 2023 - academic.oup.com
It is 24 years since the IPD-IMGT/HLA Database, http://www. ebi. ac. uk/ipd/imgt/hla/, was
first released, providing the HLA community with a searchable repository of highly curated …

NK cells and solid tumors: therapeutic potential and persisting obstacles

L Tong, C Jiménez-Cortegana, AHM Tay, S Wickström… - Molecular cancer, 2022 - Springer
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …

Natural killer cells and other innate lymphoid cells in cancer

L Chiossone, PY Dumas, M Vienne… - Nature Reviews …, 2018 - nature.com
Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

Influence of the tumor microenvironment on NK cell function in solid tumors

O Melaiu, V Lucarini, L Cifaldi, D Fruci - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …

Chimeric antigen receptor expressing natural killer cells for the immunotherapy of cancer

RS Mehta, K Rezvani - Frontiers in immunology, 2018 - frontiersin.org
Adoptive cell therapy has emerged as a powerful treatment for advanced cancers resistant
to conventional agents. Most notable are the remarkable responses seen in patients …

Targeting natural killer cells in solid tumors

G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

J Hsu, JJ Hodgins, M Marathe… - The Journal of …, 2018 - Am Soc Clin Investig
Checkpoint blockade immunotherapy targeting the PD-1/PD-L1 inhibitory axis has produced
remarkable results in the treatment of several types of cancer. Whereas cytotoxic T cells are …

Natural killer cell-mediated immunosurveillance of human cancer

KJ Malmberg, M Carlsten, A Björklund, E Sohlberg… - Seminars in …, 2017 - Elsevier
The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains
debatable. Here, we discuss advances in several areas of human NK cell research, many of …