The Cardioprotective and Anticancer Effects of SGLT2 Inhibitors: JACC: CardioOncology State-of-the-Art Review

MS Dabour, MY George, MR Daniel, AH Blaes… - Cardio Oncology, 2024 - jacc.org
Abstract Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally approved for type 2
diabetes mellitus, have demonstrated efficacy in reducing cardiovascular events, particularly …

Endothelial injury and dysfunction with emerging immunotherapies in multiple myeloma, the impact of COVID-19, and endothelial protection with a focus on the …

CC Mo, E Richardson, E Calabretta, F Corrado… - Blood Reviews, 2024 - Elsevier
Patients with multiple myeloma (MM) were among the groups impacted more severely by the
COVID-19 pandemic, with higher rates of severe disease and COVID-19-related mortality …

Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond

M Camilli, M Viscovo, L Maggio, A Bonanni… - Basic Research in …, 2024 - Springer
Sodium–glucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and
approved for treatment of diabetes mellitus, have been shown to exert pleiotropic metabolic …

Empagliflozin Alleviates Carfilzomib-Induced Cardiotoxicity in Mice by Modulating Oxidative Stress, Inflammatory Response, Endoplasmic Reticulum Stress, and …

MY George, MS Dabour, E Rashad, BN Zordoky - Antioxidants, 2024 - mdpi.com
Carfilzomib is an irreversible proteasome inhibitor used for multiple myeloma patients.
However, carfilzomib treatment is associated with cardiovascular complications …

The proteasome inhibitor carfilzomib exerts anti-inflammatory and antithrombotic effects on the endothelium

A Hjazi, CG Maroto, ME Rodriguez-Gutierrez… - Journal of Thrombosis …, 2024 - Elsevier
Background Carfilzomib (CFZ) is a second-generation proteasome inhibitor used to treat
multiple myeloma. Potent inhibition of the proteasome results in chronic proteotoxic …

Thromboembolic risk of carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for newly diagnosed multiple myeloma: A comparative …

BA Costa, TA Costa, SD Saravia, N Felix… - American Journal of …, 2024 - Wiley Online Library
Thrombosis represents a frequent and potentially severe complication in individuals
diagnosed with multiple myeloma (MM). These events can be driven by both the disease as …

Deciphering the Causal Relationship between Sodium-glucose Cotransporter 2 Inhibition and Cancer Risks: A Comprehensive Mendelian Randomization Study

L Zhang, B Xue, F Yu, Y Yin, S Jin - Journal of Cancer, 2024 - jcancer.org
Background: Controversy persists regarding the effects of sodium-glucose cotransporter 2
(SGLT2) inhibitors on cancer. The underlying causal relationship remains unclear. Method …

Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest

T Hua, Y Chu, M Wang, Y Zhang, W Shi… - Intensive Care Medicine …, 2023 - Springer
Background Currently, most patients with cardiac arrest (CA) show reversible myocardial
dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological …

Editorial for the IJMS Special Issue on Sglt2 Inhibitors (Volume 2)

A Lymperopoulos - International Journal of Molecular Sciences, 2023 - mdpi.com
The goal of the second volume of this Special Issue was to build upon the success of the first
one and to continue to highlight the ever-expanding list of pharmacological properties of the …

Editorial to the IJMS Special Issue on Sglt2 Inhibitors Vol. 1

A Lymperopoulos - Int. J. Mol. Sci - europepmc.org
The goal of this Special Issue is to highlight the ever-increasing progress in pharmacological
research on sodium-glucose co-transporter (SGLT) type 2 (SGLT2) inhibitors or gliflozins …