Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even
organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon …

Stroke is the third cause of death worldwide and the main cause of chronic, severe adult
disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all …

Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …

Homocysteine (Hcy) is a toxic, sulfur-containing intermediate of methionine metabolism.
Hyperhomocysteinemia (hHcy), as a consequence of impaired Hcy metabolism or defects in …

The prevalence and incidence of stroke rises with life expectancy. However, except for the
use of recombinant tissue-type plasminogen activator, the translation of new therapies for …

Accumulating evidence indicates that various classes of non-coding RNAs (ncRNAs)
including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and long non-coding …

Ischemia-reperfusion (I/R) physiology, also called reperfusion injury, is a fundamental
vascular pathobiological paradigm, which instigates vascular and tissue injury in a variety of …

Stroke is one of the leading causes of morbidity and mortality worldwide, and it is increasing
in prevalence. The limited therapeutic window and potential severe side effects prevent the …

Introduction Intermittent hypoxic–hyperoxic training (IHHT) may complement a multimodal
training intervention (MTI) for improving cognitive function and exercise tolerance in geriatric …

Abstract Objective Ischaemia/reperfusion (I/R) injury is defined as the damage to the tissue
which is caused when blood supply returns to tissue after ischaemia. To protect the …