[HTML][HTML] Microglia mediated neuroinflammation: focus on PI3K modulation
Immune activation in the central nervous system involves mostly microglia in response to
pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory …
pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory …
[HTML][HTML] Regulation of autophagy via carbohydrate and lipid metabolism in cancer
Simple Summary The metabolism of carbohydrates and lipids is essential to meet the
diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function …
diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function …
[HTML][HTML] Mechanisms of exercise-induced hypoalgesia
The purpose of this study was to examine opioid and endocannabinoid mechanisms of
exercise-induced hypoalgesia (EIH). Fifty-eight men and women (mean age= 21 years) …
exercise-induced hypoalgesia (EIH). Fifty-eight men and women (mean age= 21 years) …
[HTML][HTML] The involvement of polyunsaturated fatty acids in apoptosis mechanisms and their implications in cancer
M Montecillo-Aguado, B Tirado-Rodriguez… - International Journal of …, 2023 - mdpi.com
Cancer is a significant global public health issue and, despite advancements in detection
and treatment, the prognosis remains poor. Cancer is a complex disease characterized by …
and treatment, the prognosis remains poor. Cancer is a complex disease characterized by …
[HTML][HTML] Endocannabinoids, related compounds and their metabolic routes
Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …
the primary molecular targets responsible for the pharmacological effects of the Δ9 …
[HTML][HTML] The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor …
S Aquila, M Santoro, A Caputo, ML Panno, V Pezzi… - Cells, 2020 - mdpi.com
Recent studies conducted over the past 10 years evidence the intriguing role of the tumor
suppressor gene Phosphatase and Tensin Homolog deleted on Chromosome 10 PTEN in …
suppressor gene Phosphatase and Tensin Homolog deleted on Chromosome 10 PTEN in …
Emerging class of omega-3 fatty acid endocannabinoids & their derivatives
Cannabinoid receptor activation is involved in homeostatic regulation of the body. These
receptors are activated by cannabinoids, that include the active constituents of Cannabis …
receptors are activated by cannabinoids, that include the active constituents of Cannabis …
[HTML][HTML] Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling
C Manca, B Boubertakh, N Leblanc, T Deschênes… - Journal of lipid …, 2020 - ASBMB
The gut microbiota is a unique ecosystem of microorganisms interacting with the host
through several biochemical mechanisms. The endocannabinoidome (eCBome), a complex …
through several biochemical mechanisms. The endocannabinoidome (eCBome), a complex …
The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation
Notwithstanding the ongoing debate on their full potential in health and disease, there is
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …
[HTML][HTML] Algae-derived bioactive compounds with anti-lung cancer potential
Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung
cancer potential are of a great interest and considered as very promising alternative to …
cancer potential are of a great interest and considered as very promising alternative to …