Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

Because of its impact on multiple biological pathways, heparanase has emerged as a major
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …

Brain metastatic breast cancer (BMBC) is uniformly fatal and increasing in frequency.
Despite its devastating outcome, mechanisms causing BMBC remain largely unknown. The …

In recent years, heparanase has attracted considerable attention as a promising target for
innovative pharmacological applications. Heparanase is a multifaceted protein endowed …

Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity
implicated in tumor inflammation, angiogenesis, and metastasis. Heparanase is secreted as …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

Heparanase activity is strongly implicated in structural remodeling of the extracellular matrix,
a process which can lead to invasion by tumor cells. In addition, heparanase augments …

Heparanase (HPSE) is a potent protumorigenic, proangiogenic, and prometastatic enzyme
that is overexpressed in brain metastatic breast cancer (BMBC). However, little is known …

Heparanase (HPSE) is an endoglycosidase that catalyses the cutting of the side chains of
heparan-sulphate proteoglycans (HS), thus determining the remodelling of the extracellular …

Heparanase is an endo‐β‐d‐glucuronidase capable of cleaving heparan sulfate side chains
at a limited number of sites, yielding heparan sulfate fragments of still appreciable size …