Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti …
Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
Clinical relevance of tumor microenvironment: Immune cells, vessels, and mouse models
The tumor microenvironment (TME) plays a crucial role in tumor progression, therapeutic
response, and patient outcomes. TME includes immune cells, blood and lymphatic vessels …
response, and patient outcomes. TME includes immune cells, blood and lymphatic vessels …
Noninvasive detection of any-stage cancer using free glycosaminoglycans
Cancer mortality is exacerbated by late-stage diagnosis. Liquid biopsies based on genomic
biomarkers can noninvasively diagnose cancers. However, validation studies have …
biomarkers can noninvasively diagnose cancers. However, validation studies have …
A renal cell carcinoma tumorgraft platform to advance precision medicine
Renal cell carcinoma (RCC) encompasses a heterogenous group of tumors, but
representative preclinical models are lacking. We previously showed that patient-derived …
representative preclinical models are lacking. We previously showed that patient-derived …
Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
LS Cooley, J Rudewicz, W Souleyreau, A Emanuelli… - Molecular cancer, 2021 - Springer
Abstract Background Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate
of 10% in metastatic patients. Main reasons of therapy failure are lack of validated …
of 10% in metastatic patients. Main reasons of therapy failure are lack of validated …
Models of renal cell carcinoma used to investigate molecular mechanisms and develop new therapeutics
Modeling renal cell carcinoma is critical to investigating tumor biology and therapeutic
mechanisms. Multiple systems have been developed to represent critical components of the …
mechanisms. Multiple systems have been developed to represent critical components of the …
[HTML][HTML] From kidney injury to kidney cancer
Epidemiological studies document strong associations between acute or chronic kidney
injury and kidney tumors. However, whether these associations are linked by causation, and …
injury and kidney tumors. However, whether these associations are linked by causation, and …
Endoplasmic reticulum stress in renal cell carcinoma
M Correia de Sousa, E Delangre, M Türkal… - International Journal of …, 2023 - mdpi.com
The endoplasmic reticulum is an organelle exerting crucial functions in protein production,
metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells …
metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells …
Testing cancer immunotherapy in a human immune system mouse model: correlating treatment responses to human chimerism, therapeutic variables and immune …
JA Marín-Jiménez, A Capasso, MS Lewis… - Frontiers in …, 2021 - frontiersin.org
Over the past decade, immunotherapies have revolutionized the treatment of cancer.
Although the success of immunotherapy is remarkable, it is still limited to a subset of …
Although the success of immunotherapy is remarkable, it is still limited to a subset of …
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma
Abstract Polo-like kinase 1 (Plk1) expression is inversely correlated with survival
advantages in many cancers. However, molecular mechanisms that underlie Plk1 …
advantages in many cancers. However, molecular mechanisms that underlie Plk1 …