Homologous recombination (HR) plays an important role in maintaining genomic integrity. It
is responsible for repair of the most harmful DNA lesions, DNA double-strand breaks and …

Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet,
replication-mediated genomic instability is integral to oncogenesis, and p53 mutations …

Homologous recombination (HR) is a major DNA repair pathway and therefore essential for
maintaining the integrity of the genome. HR is catalyzed by proteins encoded by genes of …

Rad52 plays essential roles in homology-dependent double-strand break repair. Various
studies have established the functions of Rad52 in Rad51-dependent and Rad51 …

Abstract RADiation sensitive52 (RAD52) mediates RAD51 loading onto single-stranded
DNA ends, thereby initiating homologous recombination and catalyzing DNA annealing …

Genome integrity is maintained during DNA replication by coordination of various replisome-
regulated processes. Although it is known that Timeless (Tim) is a replisome component that …

Rad51 plays a key role in the repair of DNA double-strand breaks through homologous
recombination, which is the central process in the maintenance of genomic integrity. Five …

Proteins of the RAD52 epistasis group play an essential role in repair of some types of DNA
damage and genetic recombination. In Schizosaccharomyces pombe, Rad22 (a Rad52 …

Classically, p53 tumor-suppressor acts in transcription, apoptosis, and cell-cycle arrest. Yet,
replication-mediated genomic instability is integral to oncogenesis, and p53 mutations …

Background The homologous recombination (HR) pathway is vital for maintaining genomic
integrity through the restoration of double-stranded breaks and interstrand crosslinks. The …