The recent cloning and sequencing of several insect vitellogenins (Vg), the major yolk
protein precursor of most oviparous animals, and the mosquito Vg receptor (VgR) has …

Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are
inadequate due to toxicity, the development of drug resistance and an inability to eliminate …

Publisher Summary Although there are several reports of Leishmania parasitizing cells other
than macrophages or even existing extracellularly in mammalian tissue, it is generally …

It is difficult to eradicate cancer cells in vivo because they share with normal cells, for
themost part, the same biochemical machinery. There is no cytotoxic substance that is …

Sterols are constituents of the cellular membranes that are essential for their normal
structure and function. In mammalian cells, cholesterol is the main sterol found in the various …

Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …

Lipids were long believed to have a structural role in biomembranes and a role in energy
storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last …

The requirement of cholesterol for internalization of eukaryotic pathogens like protozoa
(Leishmaniasis, Malaria and Toxoplasmosis) and the exchange of cholesterol along with …

The flagellum and flagellar pocket are distinctive organelles present among all of the
trypanosomatid protozoa. Currently, recognized functions for these organelles include …

In T. brucei, a transferrin-binding protein has been found to share sequence homology with
pESAG-7 and-6, the products of two related genes present in the VSG gene polycistronic …