Dysregulation of epigenetic mechanisms of gene expression in the pathologies of hyperhomocysteinemia

J Perła-Kaján, H Jakubowski - International journal of molecular sciences, 2019 - mdpi.com
Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …

Life-threatening course in coronavirus disease 2019 (COVID-19): Is there a link to methylenetetrahydrofolic acid reductase (MTHFR) polymorphism and …

M Karst, J Hollenhorst, J Achenbach - Medical Hypotheses, 2020 - Elsevier
As the current COVID-19 pandemic develops and epidemiological data reveals differences
in geographical spread as well as risk factors for developing a severe course of illness …

DNA Methylation and Non-Coding RNAs in Metabolic Disorders: Epigenetic Role of Nutrients, Dietary Patterns, and Weight Loss Interventions for Precision Nutrition

CF Nicoletti, TS Assmann, LL Souza, JA Martinez - Lifestyle Genomics, 2024 - karger.com
Background: Dysregulation of epigenetic processes and abnormal epigenetic profiles are
associated with various metabolic disorders. Nutrition, as an environmental factor, can …

[HTML][HTML] Nutritional epigenomics and age-related disease

SD Amenyah, M Ward, JJ Strain, H McNulty… - Current developments in …, 2020 - Elsevier
Recent advances in epigenetic research have enabled the development of epigenetic
clocks, which have greatly enhanced our ability to investigate molecular processes that …

Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype

SD Amenyah, A McMahon, M Ward, J Deane… - Biochimie, 2020 - Elsevier
DNA methylation is important in regulating gene expression and genomic stability while
aberrant DNA methylation is associated with disease. Riboflavin (FAD) is a cofactor for …

miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis

MC Coêlho, IC Queiroz, JMC Viana Filho… - Journal of applied oral …, 2020 - SciELO Brasil
Genetic and epigenetic changes have been associated with periodontitis in various genes;
however, little is known about genes involved in epigenetic mechanisms and in oxidative …

Homocysteine concentration and adenosine A2A receptor production by peripheral blood mononuclear cells in coronary artery disease patients

P Deharo, M Marlinge, C Guiol, D Vairo… - Journal of Cellular …, 2020 - Wiley Online Library
Hyperhomocysteinemia is associated with coronary artery disease (CAD). The mechanistic
aspects of this relationship are unclear. In CAD patients, homocysteine (HCy) concentration …

DNMT3B (rs2424913) polymorphism is associated with systemic lupus erythematosus alone and with co-existing periodontitis in a Brazilian population

LNS Dias, MC Coêlho, DC Persuhn… - Journal of Applied Oral …, 2022 - SciELO Brasil
The association between Periodontitis and Systemic Lupus Erythematosus (SLE) has been
primarily based on their similar pathophysiology and both are associated with genetic …

[HTML][HTML] Investigating the Matrix of Factor V Leiden (G1691A), Factor II Prothrombin (G2021A), MTHFR C677T and A1298G Polymorphisms in Greek Population: A …

M Spanoudaki, A Itziou, A Cheimaras, O Tsiripidis… - Medical …, 2024 - mdpi.com
Background: Thrombophilia, characterized by an increased risk of thrombosis, can result
from genetic polymorphisms in clotting factors. This study aims to investigate the prevalence …

[HTML][HTML] MTHFR Gene Polymorphisms and DNA Methylation in Idiopathic Spontaneous Preterm Birth

S Dević Pavlić, R Šverko, A Barišić, T Mladenić… - Medicina, 2024 - mdpi.com
Background and Objectives: Preterm birth (PTB) is a complex condition with various
contributing factors, including genetic and epigenetic influences such as DNA methylation …