In recent years, it has become apparent that coronary microvascular dysfunction plays a
pivotal pathogenic role in angina pectoris. Functional and structural mechanisms can affect …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …

With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …

Heart failure is a complex syndrome responsible for high rates of death and hospitalization.
Ischemic heart disease is one of the most frequent causes of heart failure and it is normally …

A review is presented of the physical principles governing the distribution of blood flow and
blood pressure in the vascular system. The main factors involved are the pulsatile driving …

Blood flow (BF) increases with increasing exercise intensity in skeletal, respiratory, and
cardiac muscle. In humans during maximal exercise intensities, 85% to 90% of total cardiac …

Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a
condition consisting of a combination of altered vasomotion and long-term structural change …

Aims This study investigates whether increased right ventricular (RV) pressure in pulmonary
hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion. Methods In 25 …

Background—In vitro studies suggest that phosphorylation of titin reduces myocyte/myofiber
stiffness. Titin can be phosphorylated by cGMP-activated protein kinase. Intracellular cGMP …