Polysialic acid (polySia, PSA) is a unique constituent of the glycocalyx on the surface of
bacterial and vertebrate cells. In vertebrates, its biosynthesis is highly regulated, not only in …

Abstract About 2–3 million years ago, Alu‐mediated deletion of a critical exon in the CMAH
gene became fixed in the hominin lineage ancestral to humans, possibly through a stepwise …

Biallelic genetic variants in N-acetylneuraminic acid synthase (NANS), a critical enzyme in
endogenous sialic acid biosynthesis, are clinically associated with neurodevelopmental …

Endothelial cells are sensitive to mechanical stress and respond differently to oscillatory flow
versus unidirectional flow. This review highlights the mechanisms by which a wide range of …

Polysialic acid (polySia, PSA) is a unique and functionally important glycan, particularly in
vertebrate brains. It is involved in higher brain functions such as learning, memory, and …

Sialic acid (Sia) is involved in many biological activities and commonly occurs as a
monosialyl residue at the nonreducing terminal end of glycoconjugates. The loss of activity …

The decrease in β1-adrenergic receptor responsiveness in heart failure is attributed
conventionally to agonist-dependent desensitization. We identify elastase-dependent β1 …

Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues
upon elastase-based proteolysis of the exposed reactive center loop (RCL). However, the …

Polysialic acid (polySia) is mainly found as a modification of neural cell adhesion molecule
(NCAM) in whole embryonic brains, as well as restricted areas of adult vertebrate brains …

Polysialic acid (polySia) is a linear homopolymer of sialic acid and mainly modifies neural
cell adhesion molecule. PolySia plays important roles in synapse formation, learning and …