UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the
production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …

The most practical approach to reduce the morbidity and mortality of cancer is to delay the
process of carcinogenesis through the use of chemopreventive agents. This necessitates …

In the symbiotic association of plants and arbuscular mycorrhizal (AM) fungi, the fungal
symbiont resides in the root cortical cells where it delivers mineral nutrients to its plant host …

The measurement of the effect of new chemical entities on human UDP-
glucuronosyltransferase (UGT) marker activities using in vitro experimentation represents an …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

During the process of drug discovery, the pharmaceutical industry is faced with numerous
challenges. One challenge is the successful prediction of the major routes of human …

Gilbert's disease leads to intermittent non‐hemolytic hyperbilirubinemia by a reduction of
hepatic bilirubin glucuronidation associated with the presence of the UDP …