The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
Redox regulation in cancer: a double‐edged sword with therapeutic potential
A Acharya, I Das, D Chandhok… - Oxidative medicine and …, 2010 - Wiley Online Library
Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the
production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS …
production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS …
A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
S Oda, T Fukami, T Yokoi, M Nakajima - Drug metabolism and …, 2015 - Elsevier
UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics
Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …
Curcumin for chemoprevention of colon cancer
JJ Johnson, H Mukhtar - Cancer letters, 2007 - Elsevier
The most practical approach to reduce the morbidity and mortality of cancer is to delay the
process of carcinogenesis through the use of chemopreventive agents. This necessitates …
process of carcinogenesis through the use of chemopreventive agents. This necessitates …
Two Medicago truncatula Half-ABC Transporters Are Essential for Arbuscule Development in Arbuscular Mycorrhizal Symbiosis
Q Zhang, LA Blaylock, MJ Harrison - The Plant Cell, 2010 - academic.oup.com
In the symbiotic association of plants and arbuscular mycorrhizal (AM) fungi, the fungal
symbiont resides in the root cortical cells where it delivers mineral nutrients to its plant host …
symbiont resides in the root cortical cells where it delivers mineral nutrients to its plant host …
Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors
RL Walsky, JN Bauman, K Bourcier, G Giddens… - Drug Metabolism and …, 2012 - ASPET
The measurement of the effect of new chemical entities on human UDP-
glucuronosyltransferase (UGT) marker activities using in vitro experimentation represents an …
glucuronosyltransferase (UGT) marker activities using in vitro experimentation represents an …
Transcriptional regulation of human UDP-glucuronosyltransferase genes
Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …
Reaction phenotyping: advances in the experimental strategies used to characterize the contribution of drug-metabolizing enzymes
MA Zientek, K Youdim - Drug Metabolism and Disposition, 2015 - ASPET
During the process of drug discovery, the pharmaceutical industry is faced with numerous
challenges. One challenge is the successful prediction of the major routes of human …
challenges. One challenge is the successful prediction of the major routes of human …
[PDF][PDF] Gilbert's disease and atazanavir: From phenotype to UDP‐glucuronosyltransferase haplotype
TO Lankisch, U Moebius, M Wehmeier, G Behrens… - …, 2006 - Wiley Online Library
Gilbert's disease leads to intermittent non‐hemolytic hyperbilirubinemia by a reduction of
hepatic bilirubin glucuronidation associated with the presence of the UDP …
hepatic bilirubin glucuronidation associated with the presence of the UDP …