Multidrug resistance in cancer is linked to expression of the P-glycoprotein multidrug
transporter (Pgp, ABCB1), which exports many structurally diverse compounds from cells …

ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out
essential substrate transport reactions across cell membranes. Their transmembrane …

P-Glycoprotein (Pgp) is one of the best characterized ABC transporters, often involved in the
multidrug-resistance phenotype overexpressed by several cancer cell lines. Experimental …

Abstract ABCB1 (P-glycoprotein/P-gp) is an ATP-binding cassette transporter well known for
its association with multidrug resistance in cancer cells. Powered by the hydrolysis of ATP, it …

The drug efflux pump P-glycoprotein (P-gp) has been shown to promote multidrug
resistance (MDR) in tumors as well as to influence ADME properties of drug candidates …

The ABC transporter P-glycoprotein (P-gp) actively transports a wide range of drugs and
toxins out of cells, and is therefore related to multidrug resistance and the ADME profile of …

ATP‐binding cassette (ABC) transporters are fascinating molecular machines that are
capable of transporting a large variety of chemically diverse compounds. The energy …

ATP-binding cassette transporters mediate the transbilayer movement of a vast number of
substrates in or out of cells in organisms ranging from bacteria to humans. Current …

Overexpression of the xenotoxin transporter P-glycoprotein (P-gp) represents one major
reason for the development of multidrug resistance (MDR), leading to the failure of antibiotic …

Inflammatory bowel disease (IBD) represents a chronic inflammation of the gastrointestinal
tract characterized by an overreaction of immune responses and damage at the intestinal …