Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

The acquisition of genomic instability is a crucial feature in tumor development and there are
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …

The cytokinesis-block micronucleus cytome assay is a comprehensive system for measuring
DNA damage, cytostasis and cytotoxicity. DNA damage events are scored specifically in …

The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

Cancer is a disease in which many of the characteristics of normal cell behavior are lost or
perturbed. Uncontrolled cell proliferation and inappropriate cell survival are common …

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells.
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …

Aneuploidy has been recognized as a common characteristic of cancer cells for> 100 years.
Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …