Diabetes mellitus and cardiovascular disease: Emerging therapeutic approaches

AM Schmidt - Arteriosclerosis, thrombosis, and vascular biology, 2019 - Am Heart Assoc
Cardiovascular disease remains a leading cause of morbidity and mortality in people with
types 1 or 2 diabetes mellitus. Although beneficial roles for strict control of hyperglycemia …

New anti-hyperglycaemic agents for type 2 diabetes and their effects on diabetic retinopathy

M Saw, VW Wong, IV Ho, G Liew - Eye, 2019 - nature.com
There has been an increase in the range of non-insulin anti-hyperglycaemic agents used to
treat type 2 diabetes. With the globally rising rates of type 2 diabetes and complications such …

The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice

PH Reis-Barbosa, IA Marcondes-de-Castro… - Clinics and Research in …, 2022 - Elsevier
Purpose The liver regulates lipid metabolism. Decreasing mTOR (mechanistic target of
rapamycin complex 1) and enhancing AMPK (AMP-activated protein kinase) help degrade …

Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment

T de Souza Marinho, FF Martins… - Biochimie, 2022 - Elsevier
There are significant injuries of pancreatic islets due to obesity and insulin resistance.
Therefore, GLP-1 receptor agonists like Semaglutide might benefit the islet structural …

Effects of glucagon-like peptide 1 receptor agonists on comorbidities in older patients with diabetes mellitus

OF Onoviran, D Li, S Toombs Smith… - … advances in chronic …, 2019 - journals.sagepub.com
Elderly patients with diabetes are at high risk of polypharmacy because of multiple
coexisting diseases and syndromes. Polypharmacy increases the risk of drug–drug and …

Effect of semaglutide on coronary atherosclerosis progression in patients with type II diabetes: rationale and design of the semaglutide treatment on coronary …

S Hamal, L Cherukuri, K Shaikh… - Coronary artery …, 2020 - journals.lww.com
Background: Cardiovascular morbidity and mortality are a major burden in patients with type
2 diabetic mellitus. In a landmark study, semaglutide (an injectable glucagon like peptide-1 …

[PDF][PDF] Comprehensive review of glucagon-like peptide 1 receptor agonist treatment on the risk of cardiovascular outcomes and retinopathy as diabetic complications.

H Liu, JT Zhang, SH Xin, WN Ren… - European Review for …, 2023 - europeanreview.org
Cardiovascular and microvascular disorders are serious complications of diabetes. Intensive
glucose control is believed to hinder the pathological progression of these complications. In …

SUSTAIN program: klinikai eredmények [SUSTAIN trial program: clinical results]

Z Balogh - DIABETOLOGIA HUNGARICA, 2019 - real.mtak.hu
A 2-es típusú diabetes mellitus korábbi, döntően a glykaemiás kontrollra fókuszáló terápiás
megközelítése helyett a legújabb nemzetközi ajánlások multifaktoriális kezelést preferálnak …