Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …

Large animal models in regenerative medicine and tissue engineering: to do or not to do

I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Animal models of osteoarthritis: classification, update, and measurement of outcomes

EL Kuyinu, G Narayanan, LS Nair… - Journal of orthopaedic …, 2016 - Springer
Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

[HTML][HTML] Models of osteoarthritis: the good, the bad and the promising

PJ Cope, K Ourradi, Y Li, M Sharif - Osteoarthritis and cartilage, 2019 - Elsevier
Osteoarthritis (OA) is a chronic degenerative disease of diarthrodial joints most commonly
affecting people over the age of forty. The causes of OA are still unknown and there is much …

Animal models of osteoarthritis: comparisons and key considerations

AM McCoy - Veterinary pathology, 2015 - journals.sagepub.com
Osteoarthritis (OA) is unquestionably one of the most important chronic health issues in
humans, affecting millions of individuals and costing billions of dollars annually. Despite …

Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function

S Chen, P Fu, H Wu, M Pei - Cell and tissue research, 2017 - Springer
The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

The benefits and limitations of animal models for translational research in cartilage repair

CJ Moran, A Ramesh, PAJ Brama, JM O'Byrne… - Journal of experimental …, 2016 - Springer
Much research is currently ongoing into new therapies for cartilage defect repair with new
biomaterials frequently appearing which purport to have significant regenerative capacity …

Useful animal models for the research of osteoarthritis

K Lampropoulou-Adamidou, P Lelovas… - European Journal of …, 2014 - Springer
Osteoarthritis (OA) is a major cause of suffering for millions of people. Investigating the
disease directly on humans may be challenging. The aim of the present study is to …

Animal models of osteoarthritis: challenges of model selection and analysis

E Teeple, GD Jay, KA Elsaid, BC Fleming - The AAPS journal, 2013 - Springer
Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of
individuals worldwide. New treatment approaches require an understanding of the …

Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery

MM Murray, BC Fleming - The American journal of sports …, 2013 - journals.sagepub.com
Background: Although anterior cruciate ligament (ACL) reconstruction is the treatment gold
standard for ACL injury, it does not reduce the risk of posttraumatic osteoarthritis. Therefore …