Drug targets are specific molecules in biological tissues and body fluids that interact with
drugs. Drug target discovery is a key component of drug discovery and is essential for the …

Generating lethal reactive oxygen species (ROS) within tumors by nanocatalytic medicines
is an advanced strategy for tumor-specific therapy in recent years. Nevertheless, the low …

Carrimycin is a synthetic macrolide antibiotic that has been shown to have anti-cancer
activity; however, its exact mechanism of action and molecular target were previously …

The selenium element is essential to some life forms and its biological-chemistry function is
mainly performed by the selenol/selenolate moiety (–SeH/–Se–) in a few selenoproteins …

This study aimed to assess the impact of dietary selenoprotein extracts from Cardamine
hupingshanensis (SePCH) on the growth, hematological parameters, selenium metabolism …

The human selenoprotein H is the only selenocysteine-containing protein that is located in
the cell's nucleolus. In vivo studies have suggested that it plays some role in DNA binding …

Liver fibrosis is a vital cause of morbidity in patients with liver diseases and developing
novel anti-fibrotic drugs is imperative. Isovalerylspiramycin I (ISP I) as a major component of …

Small cell lung cancer (SCLC) urgently needs new therapeutic approaches. We found that
the antibiotic-derived compound Isovalerylspiramycin I (ISP-I) has potent anti-tumor activity …

One of the most pressing emerging issues in bacterial resistance is multidrug-resistant
Klebsiella pneumoniae. The treatment of K. pneumoniae infections is often problematic …

Carrimycin (CA), sanctioned by China's National Medical Products Administration (NMPA) in
2019 for treating acute bronchitis and sinusitis, has recently been observed to exhibit …