Current progress of chimeric antigen receptor (CAR) T versus CAR NK cell for immunotherapy of solid tumors

A Esmaeilzadeh, K Hadiloo, M Jabbari, R Elahi - Life Sciences, 2023 - Elsevier
Equipping cancer-fighting immune cells with chimeric antigen receptor (CAR) has gained
immense attention for cancer treatment. CAR-engineered T cells (CAR T cells) are the first …

[HTML][HTML] Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC)

J Huang, Q Wu, DA Geller, Y Yan - Journal of Translational Medicine, 2023 - Springer
The pivotal role of the tumor microenvironment (TME) in the initiation and advancement of
hepatocellular carcinoma (HCC) is widely acknowledged, as it fosters the proliferation and …

Biomaterial-mediated exogenous facile coating of natural killer cells for enhancing anticancer efficacy toward hepatocellular carcinoma

AK Jangid, S Kim, HJ Kim, K Kim - Bioconjugate Chemistry, 2023 - ACS Publications
Natural killer (NK) cells exhibit a good therapeutic efficacy against various malignant cancer
cells. However, the therapeutic efficacy of plain NK cells is relatively low due to inadequate …

[HTML][HTML] Development of a deep pathomics score for predicting hepatocellular carcinoma recurrence after liver transplantation

WF Qu, MX Tian, HW Lu, YF Zhou, WR Liu… - Hepatology …, 2023 - Springer
Background and purpose Tumor recurrence after liver transplantation (LT) impedes the
curative chance for hepatocellular carcinoma (HCC) patients. This study aimed to develop a …

[HTML][HTML] A six lipid metabolism related gene signature for predicting the prognosis of hepatocellular carcinoma

K Xu, P Xia, P Liu, X Zhang - Scientific Reports, 2022 - nature.com
Globally, hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors.
Studies have shown that alterations in the tumor immune microenvironment (TIME) play a …

Application of adoptive cell therapy in hepatocellular carcinoma

D Wu, Y Li - Immunology, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) remains a global health challenge. Novel treatment
modalities are urgently needed to extend the overall survival of patients. The liver plays an …

Immune checkpoint inhibitors in the treatment of hepatocellular carcinoma

Z Akbulut, B Aru, F Aydın… - Frontiers in …, 2024 - frontiersin.org
Despite advances in cancer treatment, hepatocellular carcinoma (HCC), the most common
form of liver cancer, remains a major public health problem worldwide. The immune …

[HTML][HTML] The immunological mechanisms and therapeutic potential in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Q Li, F Chen, F Wang - Cell & Bioscience, 2022 - Springer
Acute liver failure caused by drug overdose is a significant clinical problem in developed
countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its …

[HTML][HTML] PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment

J Gao, A Xiong, J Liu, X Li, J Wang, L Zhang… - Cancer Gene …, 2024 - nature.com
This comprehensive review explores the intricate mechanisms of PANoptosis and its
implications in cancer. PANoptosis, a convergence of apoptosis, pyroptosis, and …

[HTML][HTML] The important roles of natural killer cells in liver fibrosis

M Yang, E Vanderwert, ET Kimchi… - Biomedicines, 2023 - mdpi.com
Liver fibrosis accompanies the development of various chronic liver diseases and promotes
their progression. It is characterized by the abnormal accumulation of extracellular matrix …