The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Glutamate is the principal excitatory neurotransmitter in brain. Our knowledge of the
glutamatergic synapse has advanced enormously in the last 10 years, primarily through …

Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms
including tremor and bradykinesia. The primary pathophysiology underlying PD is the …

In recent years there have been tremendous advances in our understanding of the circuitry
of the basal ganglia and our ability to predict the behavioural effects of specific cellular …

In addition to their well known roles within cells, purine nucleotides such as adenosine 5′
triphosphate (ATP) and guanosine 5′ triphosphate (GTP), nucleosides such as adenosine …

Metabotropic glutamate (mGlu) receptors have been considered as potential targets for
neuroprotective drugs, but the lack of specific drugs has limited the development of …

Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …

Following focal cerebral ischemia (“stroke”) a complex and dynamic interaction of vascular
cells, glial cells, and neurons determines the extent of the ensuing lesion. Traditionally, the …