The role of astrocytes in amyloid production and Alzheimer's disease
GR Frost, YM Li - Open biology, 2017 - royalsocietypublishing.org
Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …
Rodent models of neuroinflammation for Alzheimer's disease
A Nazem, R Sankowski, M Bacher… - Journal of …, 2015 - Springer
Alzheimer's disease remains incurable, and the failures of current disease-modifying
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta
O Sheppard, MP Coleman, CS Durrant - Journal of neuroinflammation, 2019 - Springer
Background Systemic inflammation has been linked to synapse loss and cognitive decline in
human patients and animal models. A role for microglial release of pro-inflammatory …
human patients and animal models. A role for microglial release of pro-inflammatory …
Anthocyanins improve hippocampus-dependent memory function and prevent neurodegeneration via JNK/Akt/GSK3β signaling in LPS-treated adult mice
Microglia plays a critical role in the brain and protects neuronal cells from toxins. However,
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …
[HTML][HTML] 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation
F Zhang, JG Zhang, W Yang, P Xu, YL Xiao… - Biomedicine & …, 2018 - Elsevier
Gingerol, the major component of gingerols extracted from Zingiber officinale, has been
shown to exhibit anti-inflammatory and antioxidant bioactivities. Since neuroinflammation …
shown to exhibit anti-inflammatory and antioxidant bioactivities. Since neuroinflammation …
Toxoplasmosis: a pathway to neuropsychiatric disorders
Toxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the
human central nervous system. Infection with Toxoplasma drastically alters the behaviour of …
human central nervous system. Infection with Toxoplasma drastically alters the behaviour of …
Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice
XY Zhang, JB Cao, LM Zhang, YF Li, WD Mi - Journal of …, 2015 - Springer
Background Neuroinflammation often results in enduring cognitive impairment and is a risk
factor for postoperative cognitive dysfunction. There are currently no effective treatments for …
factor for postoperative cognitive dysfunction. There are currently no effective treatments for …
IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity
AJM Chaves Filho, CNC Lima… - Progress in Neuro …, 2018 - Elsevier
Obesity and depression are among the most pressing health problems in the contemporary
world. Obesity and depression share a bidirectional relationship, whereby each condition …
world. Obesity and depression share a bidirectional relationship, whereby each condition …
[HTML][HTML] Brain inflammation induces post-synaptic changes during early synapse formation in adult-born hippocampal neurons
An inflammatory reaction in the brain is primarily characterized by activation of parenchymal
microglial cells. Microglia regulate several aspects of adult neurogenesis, ie the continuous …
microglial cells. Microglia regulate several aspects of adult neurogenesis, ie the continuous …
[HTML][HTML] Ginsenoside rg3 alleviates lipopolysaccharide-induced learning and memory impairments by anti-inflammatory activity in rats
B Lee, B Sur, J Park, SH Kim, S Kwon… - Biomolecules & …, 2013 - ncbi.nlm.nih.gov
The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve
learning and memory impairments and inflammatory reactions induced by injecting …
learning and memory impairments and inflammatory reactions induced by injecting …