Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

Alzheimer's disease remains incurable, and the failures of current disease-modifying
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …

Background Systemic inflammation has been linked to synapse loss and cognitive decline in
human patients and animal models. A role for microglial release of pro-inflammatory …

Microglia plays a critical role in the brain and protects neuronal cells from toxins. However,
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …

Gingerol, the major component of gingerols extracted from Zingiber officinale, has been
shown to exhibit anti-inflammatory and antioxidant bioactivities. Since neuroinflammation …

Toxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the
human central nervous system. Infection with Toxoplasma drastically alters the behaviour of …

Background Neuroinflammation often results in enduring cognitive impairment and is a risk
factor for postoperative cognitive dysfunction. There are currently no effective treatments for …

Obesity and depression are among the most pressing health problems in the contemporary
world. Obesity and depression share a bidirectional relationship, whereby each condition …

An inflammatory reaction in the brain is primarily characterized by activation of parenchymal
microglial cells. Microglia regulate several aspects of adult neurogenesis, ie the continuous …

The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve
learning and memory impairments and inflammatory reactions induced by injecting …