Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The
occurrence of systemic antitumor effects manifesting as regression of tumors outside of the …

Preclinical models have shown that blocking PD-1/PD-L1 pathways enhances antileukemic
responses. Azacitidine upregulates PD-1 and IFNγ signaling. We therefore conducted this …

Stereotactic body radiotherapy (SBRT) for patients with metastatic cancer, especially when
characterised by a low tumour burden (ie, oligometastatic disease), receiving targeted …

Importance There is tremendous interest in using immunotherapy to treat breast cancer, as
evidenced by the more than 290 clinical trials ongoing at the time of this narrative review …

Background Despite some successes with checkpoint inhibitors for treating cancer, most
patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor …

Considerable interest is being directed toward combining immune-checkpoint inhibition (ICI)
with radiotherapy to improve response rates to ICI, which have been disappointingly low at …

Importance Immune checkpoint inhibitors (ICIs) and radiation therapy (RT) are widely used
to treat various cancers, but little data are available to guide clinicians on ICI use …

Background Phenotypic characterization of immune cells in the bone marrow (BM) of
patients with acute myeloid leukemia (AML) is lacking. Methods T‐cell infiltration was …

The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …