[HTML][HTML] Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines
V Mouro, A Fischer - Mucosal immunology, 2022 - Elsevier
The development and deployment of vaccines against COVID-19 demonstrated major
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …
Updated insights into the T cell-mediated immune response against SARS-CoV-2: a step towards efficient and reliable vaccines
M Dhawan, AA Rabaan, MMA Fawarah, SA Almuthree… - Vaccines, 2023 - mdpi.com
The emergence of novel variants of SARS-CoV-2 and their abilities to evade the immune
response elicited through presently available vaccination makes it essential to recognize the …
response elicited through presently available vaccination makes it essential to recognize the …
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike
Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
Artificial cell membrane polymersome-based intranasal beta spike formulation as a second generation COVID-19 vaccine
JH Lam, D Shivhare, TW Chia, SL Chew, G Sinsinbar… - ACS …, 2022 - ACS Publications
Current parenteral coronavirus disease 2019 (Covid-19) vaccines inadequately protect
against infection of the upper respiratory tract. Additionally, antibodies generated by wild …
against infection of the upper respiratory tract. Additionally, antibodies generated by wild …
Structural understanding of SARS-CoV-2 virus entry to host cells
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
Recombinant protein vaccines against human betacoronaviruses: strategies, approaches and progress
A Kovalenko, E Ryabchevskaya, E Evtushenko… - International Journal of …, 2023 - mdpi.com
Betacoronaviruses have already troubled humanity more than once. In 2002–2003 and
2012, the SARS-CoV and MERS-CoV, respectively, caused outbreaks of respiratory …
2012, the SARS-CoV and MERS-CoV, respectively, caused outbreaks of respiratory …
Application of traditional vaccine development strategies to SARS-CoV-2
Over the past 150 years, vaccines have revolutionized the relationship between people and
disease. During the COVID-19 pandemic, technologies such as mRNA vaccines have …
disease. During the COVID-19 pandemic, technologies such as mRNA vaccines have …
Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
C Ávila-Nieto, J Vergara-Alert… - Nature …, 2024 - nature.com
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines
are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are …
are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are …
Next generation of multispecific antibody engineering
Multispecific antibodies recognize two or more epitopes located on the same or distinct
targets. This added capability through protein design allows these man-made molecules to …
targets. This added capability through protein design allows these man-made molecules to …
Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to …
D Pflumm, A Seidel, F Klein, R Groß, L Krutzke… - Frontiers in …, 2023 - frontiersin.org
A multitude of alterations in the old immune system impair its functional integrity. Closely
related, older individuals show, for example, a reduced responsiveness to severe acute …
related, older individuals show, for example, a reduced responsiveness to severe acute …