ATP, which is released under pathological conditions and is considered a damage-
associated molecular pattern (DAMP), activates P2X7 receptors (P2X7Rs), trimeric plasma …

The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

The P2X7 receptor mediates extracellular ATP signaling implicated in the development of
devastating diseases such as chronic pain and cancer. Activation of the P2X7 receptor leads …

Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes
after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and …

P2X7 receptor, a purinergic receptor family member, is abundantly expressed on many cells,
including immune, muscle, bone, neuron, and glia. It acts as an ATP-activated cation …

In the last two decades, there has been increasing evidence supporting non-neuronal cells
as active contributors to neurodegenerative disorders. Among glial cells, astrocytes play a …

Mitochondrial dysfunction is one of the basic hallmarks of cellular pathology in
neurodegenerative diseases. Since the metabolic activity of neurons is highly dependent on …

Painful sensations are some of the most frequent complaints of patients who are admitted to
local medical clinics. Persistent pain varies according to its causes, often resulting from local …

Anticancer therapy based on the repeated administration of oxaliplatin is limited by the
development of a neuropathic syndrome difficult to treat. Oxaliplatin neurotoxicity is based …