Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of chemicals, fuels …

Background Short-chain fatty acids (SCFAs) play important physiological roles in human
health. Adverse effects on health are known with a low or excessive concentration of SCFAs …

Succinic acid is a precursor of many important, large-volume industrial chemicals and
consumer products. It was once common knowledge that many ruminant microorganisms …

Cell proliferation requires the integration of catabolic processes to provide energy, redox
power and biosynthetic precursors. Here we show how the combination of rational design …

We present here a broad overview of the field of metabolic engineering, describing in the
first section the key fundamental principles that define and distinguish it, as well as the …

Succinic acid, a dicarboxylic acid produced as an intermediate of the tricarboxylic acid (TCA)
cycle, is one of the most important platform chemicals for the production of various high …

Advances in scientific technology in the early twentieth century have facilitated the
development of synthetic plastics that are lightweight, rigid, and can be easily molded into a …

Synthetic biology aims to develop programmable tools to perform complex functions such as
redistributing metabolic flux in industrial microorganisms. However, development of protein …

In order to decrease carbon emissions and negative environmental impacts of various
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …