[HTML][HTML] Novel matrix metalloproteinase-9 (MMP-9) inhibitors in cancer treatment
ZA Rashid, SK Bardaweel - International journal of molecular sciences, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) belong to a family of zinc-dependent proteolytic
metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the …
metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the …
Medicinal Effect, In Silico Bioactivity Prediction, and Pharmaceutical Formulation of Ageratum conyzoides L.: A Review
Goat weed (Ageratum conyzoides L.), or bandotan in Indonesia, is an herbaceous plant that
broadly grows up in both subtropical as well as tropical areas. This herb contains many …
broadly grows up in both subtropical as well as tropical areas. This herb contains many …
[HTML][HTML] Transcriptomic profiling and pathway analysis of cultured human lung microvascular endothelial cells following ionizing radiation exposure
RM Bouten, CL Dalgard, AR Soltis, JE Slaven… - Scientific Reports, 2021 - nature.com
The vascular system is sensitive to radiation injury, and vascular damage is believed to play
a key role in delayed tissue injury such as pulmonary fibrosis. However, the response of …
a key role in delayed tissue injury such as pulmonary fibrosis. However, the response of …
[HTML][HTML] Bioguided fractionation of local plants against matrix metalloproteinase9 and its cytotoxicity against breast cancer cell models: In silico and in vitro study
M Hariono, R Rollando, J Karamoy, P Hariyono… - Molecules, 2020 - mdpi.com
Matrix metalloproteinase9 (MMP9) is known to be highly expressed during metastatic cancer
where most known potential inhibitors failed in the clinical trials. This study aims to select …
where most known potential inhibitors failed in the clinical trials. This study aims to select …
Docking and molecular dynamic study of isoniazid derivatives as anti-tuberculosis drug candidate
R Mardianingrum, SRN Endah, E Suhardiana… - Chemical Data …, 2021 - Elsevier
In this research, we have designed four isoniazid derivatives, ie, isonicotinohydrazide (1-
isonicotinoyl semicarbazide, 1-thiosemi isonicotinoyl carbazide, N'-(1, 3-dimethyl-1 h …
isonicotinoyl semicarbazide, 1-thiosemi isonicotinoyl carbazide, N'-(1, 3-dimethyl-1 h …
[HTML][HTML] The pharmacological TAILS of matrix metalloproteinases and their inhibitors
Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and
protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of …
protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of …
[HTML][HTML] An integrated virtual screening of compounds from Carica papaya leaves against multiple protein targets of SARS-Coronavirus-2
The pandemic of SARS-Coronavirus-2 (Coronavirus-19) has been progressing by the
increasing trend of the cases as well as deaths with neither vaccine nor drug is rationally …
increasing trend of the cases as well as deaths with neither vaccine nor drug is rationally …
In silico study of 1-benzoyl-3-methylthiourea derivatives activity as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor candidates
R Ruswanto, AM Miftah, DH Tjahjono - Chemical Data Collections, 2021 - Elsevier
Epidermal growth factor receptor (EGFR) is one of the important receptor tyrosine kinases
(RTKs). The thiourea is widely used in drug discovery and development. Therefore, an in …
(RTKs). The thiourea is widely used in drug discovery and development. Therefore, an in …
[HTML][HTML] Bioguided fractionation of local plants against matrix metalloproteinase9 and its cytotoxicity against breast cancer cell models: In silico and in vitro study (Part …
In our previous work, the partitions (1 mg/mL) of Ageratum conyzoides (AC) aerial parts and
Ixora coccinea (IC) leaves showed inhibitions of 94% and 96%, respectively, whereas their …
Ixora coccinea (IC) leaves showed inhibitions of 94% and 96%, respectively, whereas their …
Synthesis, anticancer activity, structure–activity relationship, and molecular modeling studies of α-mangostin derivatives as hERα inhibitor
α-Mangostin is one of the secondary metabolites in mangosteen pericarp, which has been
reported to have anti-breast cancer activity. In our previous study, three α-mangostin …
reported to have anti-breast cancer activity. In our previous study, three α-mangostin …