[HTML][HTML] Effect of paraquat on cytotoxicity involved in oxidative stress and inflammatory reaction: A review of mechanisms and ecological implications

J Chen, Y Su, F Lin, M Iqbal, K Mehmood… - Ecotoxicology and …, 2021 - Elsevier
Paraquat (PQ) is a cheap and an effective herbicide, which is widely being used worldwide
to remove weeds in cultivated crop fields. However, it can cause soil and water pollution …

Behavioral tests in neurotoxin-induced animal models of Parkinson's disease

EM Prasad, SY Hung - Antioxidants, 2020 - mdpi.com
Currently, neurodegenerative diseases are a major cause of disability around the world.
Parkinson's disease (PD) is the second-leading cause of neurodegenerative disorder after …

An alternative explanation for Alzheimer's disease and Parkinson's disease initiation from specific antibiotics, gut microbiota dysbiosis and neurotoxins

K Roe - Neurochemical Research, 2022 - Springer
The late onset neuropathologies, including Alzheimer's disease and Parkinson's disease,
have become increasingly prevalent. Their causation has been linked to genetics, gut …

[HTML][HTML] Mood disturbances in Parkinson's disease: From prodromal origins to application of animal models

S Hayley, F Vahid-Ansari, H Sun, PR Albert - Neurobiology of Disease, 2023 - Elsevier
Parkinson's disease (PD) is a complex illness with a constellation of environmental insults
and genetic vulnerabilities being implicated. Strikingly, many studies only focus on the …

The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson's disease

Z Dwyer, M Chaiquin, J Landrigan, K Ayoub… - Journal of …, 2021 - Springer
Background Recent work has established that Parkinson's disease (PD) patients have an
altered gut microbiome, along with signs of intestinal inflammation. This could help explain …

Characterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson's disease

Z Dwyer, C Rudyk, K Farmer, S Beauchamp, P Shail… - Neurobiology of …, 2021 - Elsevier
The primary motor symptoms of Parkinson's disease (PD) result from the degeneration of
dopamine-producing neurons of the substantia nigra pars compacta (SNc), and often, the …

Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

C Rudyk, Z Dwyer, S Hayley… - Journal of …, 2019 - Springer
Background Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in
Parkinson's disease (PD) and is also thought to be fundamentally involved in numerous …

[HTML][HTML] Chronic unpredictable stress influenced the behavioral but not the neurodegenerative impact of paraquat

C Rudyk, Z Dwyer, J McNeill, N Salmaso, K Farmer… - Neurobiology of …, 2019 - Elsevier
The impact of psychological stressors on the progression of motor and non-motor
disturbances observed in Parkinson's disease (PD) has received little attention. Given that …

Paraquat increases Interleukin-1β in hippocampal dentate gyrus to impair hippocampal neurogenesis in adult mice

Q Li, H Xiao, Y Shao, X Chang, Y Zhang… - … and Environmental Safety, 2020 - Elsevier
Abstract Paraquat (1, 1′-dimethyl-4, 4′-bipyridium dichloride, PQ), a non-selective and
efficient herbicide, causes neuroinflammation, neurodegeneration and memory dysfunction …

Early life selective knockdown of the TrkB receptor and maternal separation modulates adult stress phenotype

N Prowse, Z Dwyer, A Thompson, T Fortin… - Behavioural Brain …, 2020 - Elsevier
Abstract Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been
implicated in mood and anxiety disorders and is upregulated by antidepressants. It has …