Bioprinting: From Tissue and Organ Development to in Vitro Models
Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …
and exponential developments in the past years. Novel biomaterial inks used for the …
The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure
The right ventricle (RV) is the major determinant of functional state and prognosis in
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure
Cardiac hypertrophy is an adaptive response to physiological and pathological overload. In
response to the overload, individual cardiac myocytes become mechanically stretched and …
response to the overload, individual cardiac myocytes become mechanically stretched and …
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale
BA Rose, T Force, Y Wang - Physiological reviews, 2010 - journals.physiology.org
Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …
Genetics of congenital heart disease
K Williams, J Carson, C Lo - Biomolecules, 2019 - mdpi.com
Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
Y Zhao, E Samal, D Srivastava - Nature, 2005 - nature.com
Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
V Garg, IS Kathiriya, R Barnes, MK Schluterman… - Nature, 2003 - nature.com
Congenital heart defects (CHDs) are the most common developmental anomaly and are the
leading non-infectious cause of mortality in newborns. Only one causative gene, NKX2-5 …
leading non-infectious cause of mortality in newborns. Only one causative gene, NKX2-5 …
Gene regulatory networks in the evolution and development of the heart
EN Olson - Science, 2006 - science.org
The heart, an ancient organ and the first to form and function during embryogenesis, evolved
by the addition of new structures and functions to a primitive pump. Heart development is …
by the addition of new structures and functions to a primitive pump. Heart development is …
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
JR Hove, RW Köster, AS Forouhar, G Acevedo-Bolton… - Nature, 2003 - nature.com
The pattern of blood flow in the developing heart has long been proposed to play a
significant role in cardiac morphogenesis. In response to flow-induced forces, cultured …
significant role in cardiac morphogenesis. In response to flow-induced forces, cultured …
[HTML][HTML] Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
Cardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells,
thought to arise from distinct embryonic precursors. We use genetic fate-mapping studies to …
thought to arise from distinct embryonic precursors. We use genetic fate-mapping studies to …