Alzheimer's disease (AD) is a major cause of dementia in the elderly. Pathologically, AD is
characterized by the accumulation of insoluble aggregates of Aβ-peptides that are …

Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …

Alzheimer's disease is characterized by the deposition of senile plaques and progressive
dementia. The molecular mechanisms that couple plaque deposition to neural system …

Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for
memory defects in AD. Signaling pathways involved in memory loss in AD are under intense …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused by an
increase in amyloid metabolism. The calcium hypothesis of AD explores how activation of …

Amyloid β (Aβ)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's
disease (AD) brain, but whether and how plaques induce these neuritic abnormalities …

Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells
to respond and adapt to constantly changing environments. In multicellular organisms, it …

Upon activation by calcineurin, the nuclear factor of activated T-cells (NFAT) translocates to
the nucleus and guides the transcription of numerous molecules involved in inflammation …

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
insidious cognitive decline and memory dysfunction. Synapse loss is the best pathological …