E-cadherin and P-cadherin are major contributors to cell–cell adhesion in epithelial tissues,
playing pivotal roles in important morphogenetic and differentiation processes during …

E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial
polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role …

Purpose The 2015 American College of Medical Genetics and Genomics–Association for
Molecular Pathology (ACMG–AMP) guidelines were a major step toward establishing a …

The loss of E-cadherin expression in association with the epithelial–mesenchymal transition
(EMT) occurs frequently during tumor metastasis. However, metastases often retain E …

Simple Summary Invasive lobular breast cancer (ILC) is a special type of breast cancer (BC)
that was first described in 1941. The diagnosis of ILC is made by microscopy of tumor …

Hereditary diffuse gastric cancer (HDGC) is the only known cancer syndrome that is
dominated by gastric adenocarcinoma. HDGC is caused by germline mutation of the CDH1 …

Genome-and exome-sequencing costs are continuing to fall, and many individuals are
undergoing these assessments as research participants and patients. The issue of …

Increased intercellular tension is associated with enhanced cell proliferation and tissue
growth. Here, we present evidence for a force-transduction mechanism that links mechanical …

The prevalence of gastric cancer (GC) differs among regions worldwide, with the highest
occurrence in east Asia. Thus, its etiology, with respect to ethnic background, environmental …

Invasive lobular breast carcinoma (ILC) is the second most common breast carcinoma (BC)
subtype and is mainly driven by loss of E‐cadherin expression. Correct classification of BC …