Histone methyltransferases (HMTs) play a critical role in gene post-translational regulation
and diverse physiological processes, and are implicated in a plethora of human diseases …

Histone demethylases play a critical role in gene transcription regulation and have been
implicated in cancer. Numerous reports have highlighted the overexpression of histone …

Abstract Glycogen synthase kinase-3 (GSK-3) is a protein kinase that can phosphorylate
over a hundred substrates and regulate cell differentiation, proliferation, and death …

Epigenetic dysregulation plays a pivotal role in the initiation and progression of various
cancers, influencing critical processes such as tumor growth, invasion, migration, survival …

Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play
an important role in controlling transcription by altering the chromatin structure. Aberrant …

Methylation-mediated gene silencing is closely related to the occurrence and development
of human tumors. The euchromatic histone lysine methyltransferase 2 (EHMT2, also known …

Herein, we report for the first time the G9a/EHMT2 inhibition and anti-Alzheimer's activities of
the drug raltitrexed. G9a is a lysine methyltransferase that mainly dimethylates the H3K9 of …

Background The role of histone methyltransferase SETDB1 in renal ischemia–reperfusion
(I/R) injury has not been explored yet. This study aims to investigate the potential …

Hematopoietic stem cell (HSC) fate decisions are dictated by epigenetic landscapes. The
Polycomb Repressive Complex 1 (PRC1) represses genes that induce differentiation …

Simple Summary T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy
arising from the aberrant proliferation of immature T-cell progenitors. Despite improved …