Background Knee osteoarthritis (OA) is one of the leading causes of disability within the
adult population. Current treatment options for OA of the knee include intra-articular (IA) …

Chronic, low-grade inflammation in osteoarthritis (OA) contributes to symptoms and disease
progression. Effective disease-modifying OA therapies are lacking, but better understanding …

Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage
degeneration. OA Patients are commonly given pharmacological treatment, but the available …

Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is important in the
regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has …

Viscosupplementation (VS) with hyaluronic acid is currently used by physicians to treat
osteoarthritis. However, many aspects of this treatment remain questionable and subject of …

Background: Recent studies have shown that intra-articular injections≤ 3 months before
total knee arthroplasty increase the risk of periprosthetic joint infection. We are aware of no …

Bone changes have always been the focus of research on osteoarthritis, but the number of
studies on synovitis has increased only over the last 10 years. Our current understanding is …

Synovial fibrosis is often found in OA, contributing heavily to joint pain and joint stiffness, the
main symptoms of OA. At this moment the underlying mechanism of OA-related synovial …

Objective—To evaluate intra-articular autologous protein solution (APS) for the treatment of
osteoarthritis in horses. Animals—40 client-owned horses with naturally occuring …

Osteoarthritis (OA), the most common form of arthritis, is characterized by progressive
cartilage destruction, concomitant adaptive osteogenesis, and loss of joint function. The …