Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

Long-time ischemia worsening transplant outcomes in vascularized composite
allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an …

Although solid organ transplantation remains the definitive management for patients with
end-stage organ failure, this ultimate treatment has been limited by the number of …

Background. Apoptosis contributes to the severity of ischemia-reperfusion injury (IRI),
limiting the use of extended criteria donors in liver transplantation (LT). Machine perfusion …

To expand the donor pool of suitable organs for transplantation, there is an increased
interest in utilizing extended criteria donor grafts (ECD). Ex-situ machine perfusion has …

Ex vivo machine perfusion (EVMP) is an emerging technique for preserving explanted solid
organs with primary application in allogeneic organ transplantation. EVMP has been …

Introduction End-ischaemic preservation of a donor liver by dual hypothermic oxygenated
machine perfusion (DHOPE) for 2 hours prior to transplantation is sufficient to mitigate …

In the era of organ machine perfusion, experimental models to optimize reconditioning of
(marginal) liver grafts are needed. Although the relevance of cytokine signatures in liver …

HMP technology has potential to increase the available donor liver organ pool for liver
transplant recipients and improve clinical outcomes after liver transplantation. Broader …

Hypothermic oxygenated machine perfusion (HOPE) can enhance organ preservation and
protect mitochondria from hypoxia-ischemic injury; however, an understanding of the …