Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human
health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent …

Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Summary Background The Millennium Declaration in 2000 brought special global attention
to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal …

This is the eighteenth global report on tuberculosis (TB) published by WHO in a series that
started in 1997. It provides a comprehensive and up-to-date assessment of the TB epidemic …

The ongoing explosion of antibiotic-resistant infections continues to plague global and US
health care. Meanwhile, an equally alarming decline has occurred in the research and …

Background The diarylquinoline TMC207 offers a new mechanism of antituberculosis action
by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug …

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the
synthesis and characterization of 1, 3-benzothiazin-4-ones (BTZs), a new class of …

Background The study documented the emergence of new forms of resistant bacilli (totally
drug-resistant [TDR] or super extensively drug-resistant [XDR] tuberculosis [TB] strains) …

Tuberculosis (TB) is a major public health concern worldwide: despite a regular, although
slow, decline in incidence over the last decade, as many as 8.6 million new cases and 1.3 …

3Current affiliation: World Health Organization, Geneva, Switzerland untreatable forms of
drug-resistant TB that had not been described previously in different parts of the world, we …