RNA metabolism is central to cellular physiopathology. Almost all the molecular pathways
underpinning biological processes are affected by the events governing the RNA life cycle …

Circular RNAs are generated from many protein-coding genes, but their role in
cardiovascular health and disease states remains unknown. Here we report identification of …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating heterogeneous disease with
still no convincing therapy. To identify the most strategically significant hallmarks for …

Amyotrophic lateral sclerosis (ALS) is manifested as skeletal muscle denervation, loss of
motor neurons and finally severe respiratory failure. Mutations of RNA-binding protein FUS …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in a
gradual loss of motor neuron function. Although ophthalmic complaints are not presently …

Loss-of-function mutations in the ribonuclease angiogenin are associated with amyotrophic
lateral sclerosis. Angiogenin has been shown to cleave transfer RNAs during stress to …

Abstract Aims Mutations in DNA/RNA‐binding factor (fused‐in‐sarcoma) FUS and
superoxide dismutase‐1 (SOD‐1) cause amyotrophic lateral sclerosis (ALS). They were …

Mutations in the gene encoding the RNA/DNA-binding protein Fused in Sarcoma (FUS)
have been detected in familial amyotrophic lateral sclerosis (ALS) patients. FUS has been …

Introduction: Removal of poorly perfused capillaries by pruning contributes to remodeling
the microvasculature to optimize oxygen and nutrient delivery. Blood flow drives this process …

Objective Sporadic and familial amyotrophic lateral sclerosis (ALS) is a fatal progressive
neurodegenerative disease that results in loss of motor neurons and, in some patients …